The simple principle: The Fuse-It liposomal carrier, which includes the siRNA, fuses with the cell membrane and then releases the siRNA directly into the cytoplasm. Thus, the siRNA is immediately incorporated into the RISC complex, leading to efficient gene knockdown without the interfering processes of endocytosis or lysosomal degradation.
Based on the charge of natural cell membranes, Fuse-It-siRNA can be used with most cell types. Especially researchers, who perform knockdown studies in sensitive primary cells, will benefit highly from the extremely low cytotoxicity. Membrane fusion with Fuse-It-siRNA provides a fast and biocompatible solution for targeted gene silencing in living cells.
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